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Sickle cells are destroyed rapidly in the bodies of people with the disease, causing anemia. .
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    The four main types of sickle cell anemia are caused by different mutations.

  • Definition.
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    Figure 10.

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    Variants in the HBB gene can also cause other abnormalities in beta-globin, leading to other types of sickle cell disease.

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  • Jul 21, 2022 · Sickle cell anemia is caused by a mutation in the HBB gene responsible for producing the beta-subunit of hemoglobin, inherited from one or both parents.
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    This causes the hydrophilic amino acids glutamic acid and valine to be replaced at the sixth position.

  • Hemoglobin is the protein in red blood cells that carries oxygen.
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